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1) a turning point in an illness, life, history (crisis)

Synonyms
UK
US
Meaning:
axis

an imaginary line around which a turning object spins

point around which something revolves

climax

the most interesting, intense, violent, energetic etc part (of an event, game, speech, storm etc)

peak, culmination

contingency

an uncertain event (especially one causing problems)

chance happening; possibility

crisis

a turning point in an illness, life, history

critical situation

crossroads

a place where two or more roads meet

intersection

emergency

(in the event of) a serious and dangerous happening or situation needing quick action

crisis, danger

pivot

a central pin or point on which something turns; something on which an argument or discussion depends

center point about which something

strait

a narrow passage of water connecting two seas; trouble; difficulty

crisis, difficulty

transition

(an act of) changing, from one condition or set of circumstances to another

change, often major

TURNING POINT as in Wiktionary
TURNING POINT as in Wikipedia